Bone marrow fibrosis: pathophysiology and clinical significance of increased bone marrow stromal fibres.

@article{Kuter2007BoneMF,
  title={Bone marrow fibrosis: pathophysiology and clinical significance of increased bone marrow stromal fibres.},
  author={David J Kuter and Barbara J Bain and Ghulam J. Mufti and Adam Bagg and R. P. Hasserjian},
  journal={British journal of haematology},
  year={2007},
  volume={139 3},
  pages={351-62}
}
In bone marrow biopsies, stromal structural fibres are detected by reticulin and trichrome stains, routine stains performed on bone marrow biopsy specimens in diagnostic laboratories. Increased reticulin staining (reticulin fibrosis) is associated with many benign and malignant conditions while increased trichrome staining (collagen fibrosis) is particularly prominent in late stages of severe myeloproliferative diseases or following tumour metastasis to the bone marrow. Recent evidence has… CONTINUE READING
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