Bone marrow failure and the telomeropathies.

  title={Bone marrow failure and the telomeropathies.},
  author={Danielle M. Townsley and Bogdan Cristian Dumitriu and Neal S. Young},
  volume={124 18},
Our understanding of the pathophysiology of aplastic anemia is undergoing significant revision, with implications for diagnosis and treatment. Constitutional and acquired disease is poorly delineated, as lesions in some genetic pathways cause stereotypical childhood syndromes and also act as risk factors for clinical manifestations in adult life. Telomere diseases are a prominent example of this relationship. Accelerated telomere attrition is the result of mutations in telomere repair genes and… CONTINUE READING
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Clonal evolution in aplastic anemia is driven by chromosomal instability rather than mutations in myeloid malignancy candidate gene

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For personal use only. on December • 2014
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