Bone marrow engraftment following unrelated donor transplantation utilizing busulfan and cyclophosphamide preparatory chemotherapy.

@article{Klein1996BoneME,
  title={Bone marrow engraftment following unrelated donor transplantation utilizing busulfan and cyclophosphamide preparatory chemotherapy.},
  author={Jared L Klein and Belinda R. Avalos and P S Belt and Cullen A Taylor and Susan A Ezzone and Mark D Scholl and Jodi Fisher and D. V. Young and Edward A. Copelan},
  journal={Bone marrow transplantation},
  year={1996},
  volume={17 4},
  pages={479-83}
}
Two major problems of unrelated donor transplantation have been an increased incidence of GVHD and graft failure. Even with HLA identity by microlymphocytotoxicity assay and non-reactive MLC, URD marrow transplant recipients have a higher incidence of graft rejection and GVHD. The preparative regimen busulfan 16 mg/kg and cyclophosphamide 120 mg/kg (BuCy2) has been shown to be at least as effective in preparation of recipients with CML of HLA-identical sibling grafts as cyclophosphamide and… CONTINUE READING