Bone marrow dosimetry for radioimmunotherapy: theoretical considerations.

@article{Sgouros1993BoneMD,
  title={Bone marrow dosimetry for radioimmunotherapy: theoretical considerations.},
  author={G. Sgouros},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={1993},
  volume={34 4},
  pages={689-94}
}
  • G. Sgouros
  • Published 1993 in
    Journal of nuclear medicine : official…
In most implementations of radioimmunotherapy, the red marrow is the dose-limiting organ. Estimates of the radioactivity concentration in this organ are usually based on blood sampling or bone marrow biopsy. This work presents a simple equation which may be used to calculate the red marrow-to-blood activity concentration ratio given the hematocrit and the red marrow extracellular fluid fraction of a patient. Also presented are a series of equations which may be used to correct the activity… CONTINUE READING