Bone marrow-derived very small embryonic-like stem cells: their developmental origin and biological significance.

@article{Kucia2007BoneMV,
  title={Bone marrow-derived very small embryonic-like stem cells: their developmental origin and biological significance.},
  author={Magdalena J Kucia and Wan Wu and Mariusz Z. Ratajczak},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2007},
  volume={236 12},
  pages={
          3309-20
        }
}
Data from our and other laboratories provide evidence that bone marrow (BM) contains a population of stem cells that expresses early developmental markers such as (1) stage-specific embryonic antigen (SSEA) and (2) transcription factors Oct-4 and Nanog. These are the markers characteristic for embryonic stem cells, epiblast stem cells, and primordial germ cells (PGC). The presence of these stem cells in adult BM supports the concept that this organ contains some population of pluripotent stem… CONTINUE READING

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