Bone marrow-derived stromal cells home to and remain in the infarcted rat heart but fail to improve function: an in vivo cine-MRI study

@article{Carr2008BoneMS,
  title={Bone marrow-derived stromal cells home to and remain in the infarcted rat heart but fail to improve function: an in vivo cine-MRI study},
  author={Carolyn A Carr and Daniel J Stuckey and Louise Tatton and Damian J Tyler and Sarah J. M. Hale and Dominic Sweeney and J{\"u}rgen E. Schneider and Enca Martin-Rendon and George K. Radda and Sian E Harding and Suzanne M. Watt and Kieran Clarke},
  journal={American Journal of Physiology - Heart and Circulatory Physiology},
  year={2008},
  volume={295},
  pages={H533 - H542}
}
Basic and clinical studies have shown that bone marrow cell therapy can improve cardiac function following infarction. In experimental animals, reported stem cell-mediated changes range from no measurable improvement to the complete restoration of function. In the clinic, however, the average improvement in left ventricular ejection fraction is around 2% to 3%. A possible explanation for the discrepancy between basic and clinical results is that few basic studies have used the magnetic… CONTINUE READING

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