Bone-marrow-derived mesenchymal stem cells promote proliferation and neuronal differentiation of Niemann-Pick type C mouse neural stem cells by upregulation and secretion of CCL2.

@article{Lee2013BonemarrowderivedMS,
  title={Bone-marrow-derived mesenchymal stem cells promote proliferation and neuronal differentiation of Niemann-Pick type C mouse neural stem cells by upregulation and secretion of CCL2.},
  author={Hyun Ju Lee and Ji Eun Kang and Jong Kil Lee and Jae-Sung Bae and Hee Kyung Jin},
  journal={Human gene therapy},
  year={2013},
  volume={24 7},
  pages={655-69}
}
Niemann-Pick type C (NP-C) disease is a neurodegenerative disorder characterized neuropathologically by ballooned neurons distended with lipid storage and widespread neuronal loss. Neural stem cells (NSC) derived from NP-C disease models have decreased ability for self-renewal and neuronal differentiation. Investigation of neurogenesis in the adult brain has suggested that NP-C disease can be overcome, or at least ameliorated, by the generation of new neurons. Bone-marrow-derived mesenchymal… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
10 Citations
43 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Regeneration of the ischemic brain by engineered stem cells

  • C. T. van Velthoven, A. Kavelaars, F van Bel
  • 2009
1 Excerpt

Similar Papers

Loading similar papers…