Bone-marrow-derived mesenchymal stem cells as a target for cytomegalovirus infection: implications for hematopoiesis, self-renewal and differentiation potential.

@article{Smirnov2007BonemarrowderivedMS,
  title={Bone-marrow-derived mesenchymal stem cells as a target for cytomegalovirus infection: implications for hematopoiesis, self-renewal and differentiation potential.},
  author={Sergey V. Smirnov and Ryhor Harbacheuski and Anita Lewis-Antes and Hua Zhu and Pranela Rameshwar and Sergei V. Kotenko},
  journal={Virology},
  year={2007},
  volume={360 1},
  pages={
          6-16
        }
}
Mesenchymal stem cells (MSCs) in bone marrow (BM) regulate the differentiation and proliferation of adjacent hematopoietic precursor cells and contribute to the regeneration of mesenchymal tissues, including bone, cartilage, fat and connective tissue. BM is an important site for the pathogenesis of human cytomegalovirus (HCMV) where the virus establishes latency in hematopoietic progenitors and can transmit after reactivation to neighboring cells. Here we demonstrate that BM-MSCs are permissive… CONTINUE READING
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