Bone marrow-derived mesenchymal stem/stromal cells reverse the sensorial diabetic neuropathy via modulation of spinal neuroinflammatory cascades

@inproceedings{Evangelista2018BoneMM,
  title={Bone marrow-derived mesenchymal stem/stromal cells reverse the sensorial diabetic neuropathy via modulation of spinal neuroinflammatory cascades},
  author={Afr{\^a}nio Ferreira Evangelista and Marcos Andr{\'e} Vannier-Santos and Gessica Sabrina de Assis Silva and Daniela Nascimento Silva and Paulo Jos{\'e} Lima Juiz and Carolina Kymie Vasques Nonaka and Ricardo Ribeiro dos Santos and Milena Botelho Pereira Soares and Cristiane Flora Villarreal},
  booktitle={Journal of Neuroinflammation},
  year={2018}
}
Diabetic neuropathy (DN) is a frequent and debilitating manifestation of diabetes mellitus, to which there are no effective therapeutic approaches. Mesenchymal stem/stromal cells (MSC) have a great potential for the treatment of this syndrome, possibly through regenerative actions on peripheral nerves. Here, we evaluated the therapeutic effects of MSC on spinal neuroinflammation, as well as on ultrastructural aspects of the peripheral nerve in DN-associated sensorial dysfunction. C57Bl/6 mice… CONTINUE READING
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