Bone marrow-derived human mesenchymal stem cells become quiescent on soft substrates but remain responsive to chemical or mechanical stimuli.

@article{Winer2009BoneMH,
  title={Bone marrow-derived human mesenchymal stem cells become quiescent on soft substrates but remain responsive to chemical or mechanical stimuli.},
  author={Jessamine P. Winer and Paul A. Janmey and Margaret E. McCormick and Makoto Funaki},
  journal={Tissue engineering. Part A},
  year={2009},
  volume={15 1},
  pages={147-54}
}
The microenvironment of bone marrow-derived human mesenchymal stem cells (hMSCs) strictly regulates their self-renewal and differentiation. Culturing these cells ex vivo leads to a rapid expansion followed by senescence, which is characterized by a lack of proliferation and differentiation. In this study, 250-Pa polyacrylamide gels, which mimics the elasticity of bone marrow and fat tissues, were coated with a mixture of collagen type 1 and fibronectin. When hMSCs were seeded sparsely on these… CONTINUE READING
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Mesenchymal stem cells: isolation, in vitro expansion and characterization

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