Bone marrow-derived endothelial progenitor cells promote hematopoietic reconstitution after hematopoietic stem cell transplantation.

@article{Yan2013BoneME,
  title={Bone marrow-derived endothelial progenitor cells promote hematopoietic reconstitution after hematopoietic stem cell transplantation.},
  author={Zhiling Yan and Ling-yu Zeng and Z Li and H Zhang and Wei-Jen Chen and Lu Jun Jia and C H Chen and Han Cheng and Jianzhong Cao and K Xu},
  journal={Transplantation proceedings},
  year={2013},
  volume={45 1},
  pages={427-33}
}
OBJECTIVE A hematopoietic deficit is a serious complication after hematopoietic stem cell transplantation. It has been shown that fetal blood-derived endothelial progenitor cells (EPCs) can promote hematopoietic reconstitution after transplantation. This study investigated whether EPCs from bone marrow (BM) of adult mice could promote hematopoietic reconstitution. METHODS Lethally irradiated BALB/c mice were administered BM cells or BM cells plus EPCs. RESULTS The results showed that EPC… CONTINUE READING

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Irradiation induces bone injury by damaging bone marrow microenvironment for stem cells.

Proceedings of the National Academy of Sciences of the United States of America • 2011

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