Bone marrow-derived clonal mesenchymal stem cells inhibit ovalbumin-induced atopic dermatitis

@inproceedings{Na2014BoneMC,
  title={Bone marrow-derived clonal mesenchymal stem cells inhibit ovalbumin-induced atopic dermatitis},
  author={Kwangmin Na and Hyun Seung Yoo and Yong Xu Zhang and M-S Choi and K. Lee and Tacghee Yi and Sun Uk Song and M-S Jeon},
  booktitle={Cell Death and Disease},
  year={2014}
}
Mesenchymal stem cells (MSCs) possess immunomodulatory activities, including suppression of T- and B-cell activation. However, their effects on atopic dermatitis (AD) have not yet been studied. Using an ovalbumin-induced AD mouse model, we investigated whether MSCs can be used as therapeutics in AD. We isolated both allogeneic and syngeneic clonal MSCs (cMSCs) from mouse bone marrow according to the subfractionation culturing method. Our cMSCs suppressed both T- and B-cell activation. T-cell… CONTINUE READING
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