Bone-marrow-derived cells that home to acoustic deafened cochlea preserved their hematopoietic identity.

@article{Tan2008BonemarrowderivedCT,
  title={Bone-marrow-derived cells that home to acoustic deafened cochlea preserved their hematopoietic identity.},
  author={Brian Tiong Gee Tan and Myranda Mui Gek Lee and Runsheng Ruan},
  journal={The Journal of comparative neurology},
  year={2008},
  volume={509 2},
  pages={167-79}
}
The high degree of bone marrow cell (BMC) plasticity has prompted us to test its restoration possibility in inner ear repair. Our aim was to determine the potential of these cells to transdifferentiate into specialized cochlea cell types after acoustic injury and BMC mobilization. Lethally irradiated mice were transplanted with BMCs from green fluorescent protein (GFP) transgenic mice and subjected to acoustic deafening 3 months later. In a separate experiment, stem cell factor and granulocyte… CONTINUE READING
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