Bone marrow-derived cells fuse with normal and transformed intestinal stem cells.

  title={Bone marrow-derived cells fuse with normal and transformed intestinal stem cells.},
  author={Adnan Z Rizvi and John R Swain and Paige S. Davies and Alexis S Bailey and Adria D. Decker and Holger Willenbring and Markus Grompe and William Harv Fleming and Melissa H Wong},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 16},
Transplanted adult bone marrow-derived cells (BMDCs) have been shown to adopt the phenotype and function of several nonhematopoietic cell lineages and promote tumorigenesis. Beyond its cancer enhancing potential, cell fusion has recently emerged as an explanation of how BMDCs regenerate diseased heptocytes, contribute to Purkinje neurons and skeletal and cardiac muscle cells, and participate in skin and heart regeneration. Although bone marrow-derived epithelial cells also have been observed in… CONTINUE READING

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Development (Cambridge, U.K

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