Bone marrow-derived cells as progenitors of lung alveolar epithelium.

  title={Bone marrow-derived cells as progenitors of lung alveolar epithelium.},
  author={Darrell N. Kotton and Bruce Yong Ma and Wellington V Cardoso and Elisabeth A Sanderson and Ross S. Summer and Mary C. Williams and Alan Fine},
  volume={128 24},
We assessed the capacity of plastic-adherent cultured bone marrow cells to serve as precursors of differentiated parenchymal cells of the lung. By intravenously delivering lacZ-labeled cells into wild-type recipient mice after bleomycin-induced lung injury, we detected marrow-derived cells engrafted in recipient lung parenchyma as cells with the morphological and molecular phenotype of type I pneumocytes of the alveolar epithelium. At no time after marrow cell injection, did we detect any… CONTINUE READING


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