Bone marrow chimeric rats reveal the unique distribution of resident and recruited macrophages in the contused rat spinal cord.

@article{Popovich2001BoneMC,
  title={Bone marrow chimeric rats reveal the unique distribution of resident and recruited macrophages in the contused rat spinal cord.},
  author={Phillip G. Popovich and William F. Hickey},
  journal={Journal of neuropathology and experimental neurology},
  year={2001},
  volume={60 7},
  pages={676-85}
}
Brain and spinal cord inflammation that develops after traumatic injury is believed to differentially influence the structural and/or physiological integrity of surviving neurons and glia. It is possible that the functional dichotomy of CNS inflammation results from the activity of a heterogeneous macrophage population elicited by trauma. Indeed, unique functions have been attributed to macrophages derived from resident microglia versus those originating from infiltrating monocytes. Thus… CONTINUE READING