Bone marrow cells regenerate infarcted myocardium

@article{Orlic2001BoneMC,
  title={Bone marrow cells regenerate infarcted myocardium},
  author={Donald Orlic and Jan Kajstura and Stefano Chimenti and Igor Jakoniuk and Stacie M. Anderson and Baosheng Li and James Pickel and Ronald D. G. McKay and Bernardo Nadal-Ginard and David M. Bodine and Annarosa Leri and Piero Anversa},
  journal={Nature},
  year={2001},
  volume={410},
  pages={701-705}
}
Myocardial infarction leads to loss of tissue and impairment of cardiac performance. The remaining myocytes are unable to reconstitute the necrotic tissue, and the post-infarcted heart deteriorates with time. Injury to a target organ is sensed by distant stem cells, which migrate to the site of damage and undergo alternate stem cell differentiation; these events promote structural and functional repair. This high degree of stem cell plasticity prompted us to test whether dead myocardium could… 
Mobilized bone marrow cells repair the infarcted heart, improving function and survival
Attempts to repair myocardial infarcts by transplanting cardiomyocytes or skeletal myoblasts have failed to reconstitute healthy myocardium and coronary vessels integrated structurally and
Bone marrow stem cells regenerate infarcted myocardium
TLDR
This research is focused on the capacity of BMSC to form new cardiac myocytes and coronary vessels following an induced myocardial infarct in adult mice and results in improved cardiac function and survival.
Stem cell repair in ischemic heart disease: An experimental model
  • D. Orlic
  • Medicine
    International journal of hematology
  • 2002
TLDR
It is demonstrated that circulating autologous stem cells traffic to the ischemic, infarcted myocardium and undergo differentiation into cardiomyocytes and vascular structures and it is concluded that adult BMSC have the potential for repair in acute, isChemic heart disease.
Transplanted Adult Bone Marrow Cells Repair Myocardial Infarcts in Mice
TLDR
In vivo findings demonstrate the capacity of highly enriched Lin− c‐kit+ adult bone marrow cells to acutely regenerate functional myocardium within an infarcted region.
Implantation of bone marrow stem cells reduces the infarction and fibrosis in ischemic mouse heart.
TLDR
It is demonstrated that cultured bone marrow stromal cells (MSCs) and Lin(-) bone marrow cells upon transplantation differentiate into myocytes and endothelial cells in the ischemic heart, eventually reducing both infarct size and fibrosis.
Bone marrow-derived B cells preserve ventricular function after acute myocardial infarction.
TLDR
Intramyocardial injection of B cells into early post-ischemic myocardium preserved cardiac function by cardiomyocyte salvage, and other BM MNC subtypes were either ineffective or suppressed cardioprotection conferred by an enriched B cell population.
Repair of Infarcted Myocardium Mediated by Transplanted Bone Marrow–Derived CD34+ Stem Cells in a Nonhuman Primate Model
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The results suggest that the improvement in regional blood flow and cardiac function in cynomolgus monkey acute myocardial infarction is not the result of generation of transplanted cell–derived endothelial cells or cardiomyocytes; and raise the possibility that angiogenic cytokines secreted from transplanted cells potentiateAngiogenic activity of endogenous cells.
Does a Newly Characterized Cell From the Bone Marrow Repair the Heart After Acute Myocardial Infarction?
TLDR
A new report in Circulation Research suggests that injection of isolated multilineage-differentiating stress enduring (MUSE) cells into the venous circulation 24 hours after acute myocardial infarction reduces scar size and adverse ventricular remodeling and improves cardiac pump function.
The role of bone marrow derived cells in cardiac repair
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Ex vivo myocardial repair processes are inadequate to compensate for pathological insults, and the mechanism of benefit appears to be induced by paracrine effects activating pro-survival pathways.
Bone marrow-derived stem cell therapy in acute myocardial infarction : an experimental porcine model
TLDR
Bone marrow-derived stem cells appear to enhance recovery of the infarcted myocardium by restoring the reduced LVEF after infarction and proteomic screening indicated that mitochondrial energy metabolism recovered after BM-MNC transplantation.
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