Bone marrow cells regenerate infarcted myocardium

@article{Orlic2001BoneMC,
  title={Bone marrow cells regenerate infarcted myocardium},
  author={D. Orlic and Jan Kajstura and S. Chimenti and I. Jakoniuk and S. Anderson and B. Li and J. Pickel and R. Mckay and B. Nadal-Ginard and D. Bodine and Annarosa Leri and P. Anversa},
  journal={Nature},
  year={2001},
  volume={410},
  pages={701-705}
}
  • D. Orlic, Jan Kajstura, +9 authors P. Anversa
  • Published 2001
  • Medicine
  • Nature
  • Myocardial infarction leads to loss of tissue and impairment of cardiac performance. The remaining myocytes are unable to reconstitute the necrotic tissue, and the post-infarcted heart deteriorates with time. Injury to a target organ is sensed by distant stem cells, which migrate to the site of damage and undergo alternate stem cell differentiation; these events promote structural and functional repair. This high degree of stem cell plasticity prompted us to test whether dead myocardium could… CONTINUE READING
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