• DOI:10.1038/35070587
Corpus ID: 4424399

Bone marrow cells regenerate infarcted myocardium

@article{Orlic2001BoneMC,
  title={Bone marrow cells regenerate infarcted myocardium},
  author={D. Orlic and Jan Kajstura and S. Chimenti and I. Jakoniuk and S. Anderson and B. Li and J. Pickel and R. Mckay and B. Nadal-Ginard and D. Bodine and Annarosa Leri and P. Anversa},
  journal={Nature},
  year={2001},
  volume={410},
  pages={701-705}
}

D. Orlic, Jan Kajstura, +9 authors P. Anversa

Published 2001

Medicine

Nature

Myocardial infarction leads to loss of tissue and impairment of cardiac performance. The remaining myocytes are unable to reconstitute the necrotic tissue, and the post-infarcted heart deteriorates with time. Injury to a target organ is sensed by distant stem cells, which migrate to the site of damage and undergo alternate stem cell differentiation; these events promote structural and functional repair. This high degree of stem cell plasticity prompted us to test whether dead myocardium could… CONTINUE READING

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