Bone marrow cells regenerate infarcted myocardium

  title={Bone marrow cells regenerate infarcted myocardium},
  author={D. Orlic and Jan Kajstura and S. Chimenti and I. Jakoniuk and S. Anderson and B. Li and J. Pickel and R. Mckay and B. Nadal-Ginard and D. Bodine and Annarosa Leri and P. Anversa},
  • D. Orlic, Jan Kajstura, +9 authors P. Anversa
  • Published 2001
  • Medicine
  • Nature
  • Myocardial infarction leads to loss of tissue and impairment of cardiac performance. The remaining myocytes are unable to reconstitute the necrotic tissue, and the post-infarcted heart deteriorates with time. Injury to a target organ is sensed by distant stem cells, which migrate to the site of damage and undergo alternate stem cell differentiation; these events promote structural and functional repair. This high degree of stem cell plasticity prompted us to test whether dead myocardium could… CONTINUE READING
    5,138 Citations

    Paper Mentions

    Interventional Clinical Trial
    A randomized study to assess the safety, feasibility and effectiveness of direct intramyocardial percutaneous delivery of autologous bone marrow-derived total mononuclear cells or… Expand
    ConditionsRefractory Angina
    Mobilized bone marrow cells repair the infarcted heart, improving function and survival
    • 2,188
    • PDF
    Bone marrow stem cells regenerate infarcted myocardium
    • 290
    Transplanted Adult Bone Marrow Cells Repair Myocardial Infarcts in Mice
    • 431
    Stem cell repair in ischemic heart disease: An experimental model
    • D. Orlic
    • Medicine
    • International journal of hematology
    • 2002
    • 35
    Bone marrow-derived B cells preserve ventricular function after acute myocardial infarction.
    • 33
    The role of bone marrow derived cells in cardiac repair
    Bone marrow-derived stem cell therapy in acute myocardial infarction : an experimental porcine model
    • 8
    • PDF


    Autologous transplantation of bone marrow cells improves damaged heart function.
    • 1,077
    • PDF
    Hematopoietic potential of stem cells isolated from murine skeletal muscle.
    • K. Jackson, T. Mi, M. Goodell
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1999
    • 996
    • PDF
    Myocyte proliferation in end-stage cardiac failure in humans.
    • 587
    • PDF
    Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice.
    • M. Eglitis, E. Mezey
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1997
    • 1,018
    • PDF
    Muscle regeneration by bone marrow-derived myogenic progenitors.
    • 2,778
    Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
    • 2,332
    • PDF
    The biology of hematopoietic stem cells.
    • 851
    • PDF
    Liver from bone marrow in humans
    • 1,215
    • PDF