Bone marrow cells recruited through the neuropilin-1 receptor promote arterial formation at the sites of adult neoangiogenesis in mice.

@article{Zacchigna2008BoneMC,
  title={Bone marrow cells recruited through the neuropilin-1 receptor promote arterial formation at the sites of adult neoangiogenesis in mice.},
  author={Serena Zacchigna and Lucia Pattarini and Lorena Zentilin and Silvia Moimas and Alessandro Carrer and Milena Sinigaglia and Nikola Arsic and Sabrina Tafuro and Gianfranco Sinagra and Mauro Giacca},
  journal={The Journal of clinical investigation},
  year={2008},
  volume={118 6},
  pages={2062-75}
}
Experimental and clinical evidence indicate that bone marrow cells participate in the process of new blood vessel formation. However, the molecular mechanisms underlying their recruitment and their exact role are still elusive. Here, we show that bone marrow cells are recruited to the sites of neoangiogenesis through the neuropilin-1 (NP-1) receptor and that they are essential for the maturation of the activated endothelium and the formation of arteries in mice. By exploiting adeno-associated… CONTINUE READING

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Characterization of a bicyclic peptide neuropilin-1 (NP-1) antagonist (EG3287) reveals importance of vascular endothelial growth factor exon 8 for NP-1 binding and role of NP-1 in KDR Signaling

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