Bone marrow cells produce a novel TSHβ splice variant that is upregulated in the thyroid following systemic virus infection

@article{Vincent2009BoneMC,
  title={Bone marrow cells produce a novel TSHβ splice variant that is upregulated in the thyroid following systemic virus infection},
  author={Bryce H Vincent and Dina Montufar-Solis and B-B Teng and Brad A Amendt and Juliane Sch{\"a}fer and John R. Klein},
  journal={Genes and Immunity},
  year={2009},
  volume={10},
  pages={18-26}
}
Although cells of the immune system can produce thyroid-stimulating hormone (TSH), the significance of that remains unclear. Using 5′ rapid amplification of cDNA ends (RACE), we show that mouse bone marrow (BM) cells produce a novel in-frame TSHβ splice variant generated from a portion of intron 4 with all of the coding region of exon 5, but none of exon 4. The TSHβ splice variant gene was expressed at low levels in the pituitary, but at high levels in the BM and the thyroid, and the protein… CONTINUE READING
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