Bone marrow angiotensin AT2 receptor deficiency aggravates atherosclerosis development by eliminating macrophage liver X receptor-mediated anti-atherogenic actions.

Abstract

BACKGROUND Bone marrow (BM) Angiotensin II (Ang II) type 1 (AT1) receptor plays a crucial role in atherosclerosis development; however, the effect of BM Ang II type 2 (AT2) receptor on atherogenesis remains undefined. METHODS AND RESULTS We generated BM chimera apoE-deficient (apoE(-/-)) mice whose BM cells were repopulated with AT2-deficient (Agtr2… (More)
DOI: 10.1177/1470320314561138

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Cite this paper

@article{Kato2015BoneMA, title={Bone marrow angiotensin AT2 receptor deficiency aggravates atherosclerosis development by eliminating macrophage liver X receptor-mediated anti-atherogenic actions.}, author={Taku Kato and Hiroyuki Kawahito and Sou Kishida and Daisuke Irie and Noriyuki Wakana and Masakazu Kikai and Hiroki Takata and Takehiro Ogata and Tomomi Ueyama and Satoaki Matoba and Hiroyuki Yamada}, journal={Journal of the renin-angiotensin-aldosterone system : JRAAS}, year={2015}, volume={16 4}, pages={936-46} }