Bone marrow angiogenesis in multiple myeloma

  title={Bone marrow angiogenesis in multiple myeloma},
  author={Angelo Vacca and Domenico Ribatti},
Angiogenesis is a constant hallmark of multiple myeloma (MM) progression and has prognostic potential. It is induced by plasma cells via angiogenic factors with the transition from monoclonal gammopathy of undetermined significance (MGUS) to MM, and probably with loss of angiostatic activity on the part of MGUS. The pathophysiology of MM-induced angiogenesis is complex and involves both direct production of angiogenic cytokines by plasma cells and their induction within the microenvironment… CONTINUE READING
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