Bone marrow angiogenesis and progression in multiple myeloma.

  title={Bone marrow angiogenesis and progression in multiple myeloma.},
  author={Angelo Vacca and Domenico Ribatti and Luisa Roncali and Girolamo Ranieri and Gabriella Serio and Francesco Silvestris and Franco Dammacco},
  journal={British journal of haematology},
  volume={87 3},
Tumour growth is angiogenesis-dependent. We found a high correlation between the extent of bone marrow angiogenesis, evaluated as microvessel area, and the proliferating (S-phase) fraction of marrow plasma cells, evaluated as labelling index (LI), in patients with multiple myeloma (MM) and in those with monoclonal gammopathies of undetermined significance (MGUS). Angiogenesis itself was significantly associated with active as opposed to non-active MM and MGUS. The highest microvessel area… CONTINUE READING