Bone marrow – derived immune cells regulate vascular disease through a p 27 Kip 1-dependent mechanism

@inproceedings{Boehm2004BoneM,
  title={Bone marrow – derived immune cells regulate vascular disease through a p 27 Kip 1-dependent mechanism},
  author={Manfred Boehm and Michelle Olive and Andrea L. True and Martin F. Crook and Hong San and Xuan Qu and Elizabeth G. Nabel},
  year={2004}
}
The cyclin-dependent kinase inhibitors are key regulators of cell cycle progression. Although implicated in carcinogenesis, they inhibit the proliferation of a variety of normal cell types, and their role in diverse human diseases is not fully understood. Here, we report that p27Kip1 plays a major role in cardiovascular disease through its effects on the proliferation of bone marrow–derived (BM-derived) immune cells that migrate into vascular lesions. Lesion formation after mechanical arterial… CONTINUE READING
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