Bone marrow–specific Cap gene deletion protects against high-fat diet–induced insulin resistance

@article{Lesniewski2007BoneMC,
  title={Bone marrow–specific Cap gene deletion protects against high-fat diet–induced insulin resistance},
  author={Lisa A. Lesniewski and Sarah E Hosch and Jaap G Neels and Carl de Luca and Mohammad Pashmforoush and Carey N Lumeng and S Chiang and Miriam Scadeng and Alan R. Saltiel and Jerrold M. Olefsky},
  journal={Nature Medicine},
  year={2007},
  volume={13},
  pages={455-462}
}
Cbl-associated protein (Cap) is a member of a phosphatidylinositol 3-kinase–independent pathway for insulin-stimulated translocation of the glucose transporter GLUT4. Despite this positive role of Cap in glucose uptake, here we show that deletion of the gene encoding Cap (official gene name: Sorbs1) protects against high-fat diet (HFD)–induced insulin resistance in mice while also having an opposite, insulin-sensitizing effect, accompanied by reduced tissue markers of inflammation. Given the… CONTINUE READING

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