Bone marrow–derived stem cells target retinal astrocytes and can promote or inhibit retinal angiogenesis

@article{Otani2002BoneMS,
  title={Bone marrow–derived stem cells target retinal astrocytes and can promote or inhibit retinal angiogenesis},
  author={Atsushi Otani and Karen Kinder and Karla L Ewalt and F. Javier Calderon Otero and Paul R. Schimmel and Martin Friedlander},
  journal={Nature Medicine},
  year={2002},
  volume={8},
  pages={1004-1010}
}
Adult bone marrow (BM) contains cells capable of differentiating along hematopoietic (Lin+) or non-hematopoietic (Lin−) lineages. Lin− hematopoietic stem cells (HSCs) have recently been shown to contain a population of endothelial precursor cells (EPCs) capable of forming blood vessels. Here we show that intravitreally injected Lin− BM cells selectively target retinal astrocytes, cells that serve as a template for both developmental and injury-associated retinal angiogenesis. When Lin− BM cells… CONTINUE READING
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