Bone marrow‐derived cells contribute to lung regeneration after elastase‐induced pulmonary emphysema

@article{Ishizawa2004BoneMC,
  title={Bone marrow‐derived cells contribute to lung regeneration after elastase‐induced pulmonary emphysema},
  author={Kota Ishizawa and Hiroshi Kubo and Mitsuhiro Yamada and Seiichi Kobayashi and Muneo Numasaki and S Ueda and Takashi Suzuki and Hidetada Sasaki},
  journal={FEBS Letters},
  year={2004},
  volume={556}
}
All‐trans retinoic acid (ATRA) is known to reverse the anatomic and physiologic signs of pulmonary emphysema. However, the origin of the progenitor cells involved in this lung regeneration remains unclear. Recently, it was shown that bone marrow could be the source of progenitor cells for several cell types. Mice with elastase‐induced emphysema were treated with ATRA, granulocyte colony‐stimulating factor (G‐CSF), or a combination of both. ATRA or G‐CSF promoted lung regeneration and increased… Expand
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