Bone marrow: ultrasmall superparamagnetic iron oxide for MR imaging.

  title={Bone marrow: ultrasmall superparamagnetic iron oxide for MR imaging.},
  author={E Sen{\'e}terre and Ralph Weissleder and Diego M. Jaramillo and Peter Reimer and Anne S. Lee and Thomas J. Brady and Jack Wittenberg},
  volume={179 2},
An ultrasmall superparamagnetic iron oxide (USPIO) preparation was evaluated as a potential intravenous contrast agent for magnetic resonance (MR) imaging of bone marrow. One hour after administration of USPIO (40, 80, and 160 mumols of iron per kilogram body weight) in rats and rabbits, T1 and T2 relaxation times were, respectively, approximately 30%, 50%, and 65% lower than precontrast relaxation times. Maximum decrease in relaxation times of marrow occurred within 1-24 hours after… CONTINUE READING

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