Bone loss is more severe in primary adrenal than in pituitary-dependent Cushing’s syndrome

@article{Minetto2004BoneLI,
  title={Bone loss is more severe in primary adrenal than in pituitary-dependent Cushing’s syndrome},
  author={Marco Alessandro Minetto and Giuseppe Reimondo and Giangiacomo Osella and Massimo Ventura and Aggeliki Angeli and Massimo Terzolo},
  journal={Osteoporosis International},
  year={2004},
  volume={15},
  pages={855-861}
}
Either exogenous or endogenous glucocorticoid excess is an established cause of osteoporosis and fractures. Glucocorticoids exert their negative effects on bone through mechanisms that are not yet completely elucidated; however, as many as 50% of patients with Cushing’s syndrome suffer from osteoporosis. Bone loss induced by glucocorticoids is potentially reversible after resolution of glucocorticoid excess. It is presently unknown if Cushing’s disease (CD) sustained by a pituitary ACTH… CONTINUE READING