Bone loss in response to long-term glucocorticoid therapy.

@article{Locascio1990BoneLI,
  title={Bone loss in response to long-term glucocorticoid therapy.},
  author={V. Locascio and E. Bonucci and B. Imbimbo and P. Ballanti and S. Adami and S. Milani and D. Tartarotti and C. DellaRocca},
  journal={Bone and mineral},
  year={1990},
  volume={8 1},
  pages={
          39-51
        }
}
A number of studies have shown that an excess of glucocorticoids induces osteoporosis, but the mechanism(s) and the time course of the reduction of bone mass remain uncertain. In order to clarify this issue we carried out a longitudinal clinical and histomorphometric study of patients requiring long-term glucocorticoid treatment. In 23 patients (9 men, 10 post- and 4 premenopausal women) biochemical and bone histomorphometric investigations were carried out before and during treatment with 10… Expand
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