Bone loss detection in rats using a mouse densitometer.

@article{Binkley2003BoneLD,
  title={Bone loss detection in rats using a mouse densitometer.},
  author={N Binkley and David B Dahl and Jean Engelke and Tisha N. Kawahara-Baccus and D Scott Krueger and Ricki J Colman},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2003},
  volume={18 2},
  pages={370-5}
}
Estrogen-depletion bone-loss studies often use ovariectomized (ovx) rats and measure bone mineral density in vivo or ex vivo using DXA. Recently, a portable densitometer (PIXImus) was developed for mouse research; however, its use in rats is unclear. This study compared the ability of PIXImus and a standard densitometer (DPXL) to detect ovx-induced bone loss in rats both in vivo and ex vivo. Additionally, instrument accuracy was assessed by comparing measured bone mass with ash weight. Finally… CONTINUE READING

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