Bone involvement in sickle cell disease

  title={Bone involvement in sickle cell disease},
  author={Antonio M Almeida and Irene Roberts},
  journal={British Journal of Haematology},
Bone involvement is the commonest clinical manifestation of sickle cell disease both in the acute setting such as painful vaso‐occlusive crises, and as a source of chronic, progressive disability such as avascular necrosis. Management of these problems is often difficult because of the diagnostic imprecision of most laboratory and imaging investigations and because of the lack of evidence for most surgical procedures in sickle cell disease. This review first discusses the acute problems related… 
Imaging of musculoskeletal manifestations in sickle cell disease patients.
The pathophysiology and key imaging findings related to these complications are reviewed and awareness and knowledge of the imaging features related toThese complications are essential for early diagnosis and prompt management.
Management of Osteomyelitis in Sickle Cell Disease: Review Article
Treatment of osteomyelitis in patients with SCD may be medical or surgical, but considerations in antibiotic selection and management preoperatively and postoperatively must be taken to ensure optimal outcomes.
Osteoarticular disorders in sickle cell disease
Different organs can be affected secondary to sickle cell disease, including the central nervous system, kidneys, gastrointestinal tract, respiratory system, cardiovascular system, bone, and joints.
Osteoarticular involvement in sickle cell disease
More detailed studies are required to understand the pathophysiological mechanisms involved in the complications of sickle cell disease and propose more adequate and specific therapies.
Idiopathic facial swelling secondary to sickle cell anaemia
A case of idiopathic facial swelling associated with sickle cell disease in a young patient is described.
The Evaluation of Bilateral Femoral Head Osteonecrosis Secondary to Sickle Cell Anemia Crisiswith Bone Scintigraphy
A 29 year old male patient who has sickle cell anemia and who has been experiencing pain and difficulty in walking for a month is chosen.
Musculoskeletal of Sickle Cell Disease 1
The clinical and radiographic features of acute osteomyelitis may be particularly difficult to distinguish from those of bone infarction; therefore, care must be taken to achieve an accurate diagnosis by identifying or excluding bone involvement.
Musculoskeletal manifestations of sickle cell disease.
The clinical and radiographic features of acute osteomyelitis may be particularly difficult to distinguish from those of bone infarction; therefore, care must be taken to achieve an accurate diagnosis by identifying or excluding bone involvement.
Dactylitis: A Complication in Patients With Sickle Cell Disease
This review will detail the problems associated with the bone and skeletal involvement in SCD with specific emphasis on dactylitis in children; description of its signs, symptoms, effects, as well as treatment procedure.
Musculoskeletal Manifestations of Sickle Cell Anaemia: A Pictorial Review
The various musculoskeletal manifestations of sickle cell disease are discussed and illustrated focusing primarily on marrow hyperplasia, osteomyelitis and septic arthritis, medullary and epiphyseal bone infarcts, growth defects, and soft tissue changes.


Bone disorders in sickle-cell disease
  • O. Onuba
  • Medicine
    International Orthopaedics
  • 2004
SummarySickle cell disease involves many organs but musculo-skeletal problems present most often with bone pain, the most common reason for admission to hospital. Two separate pathological
Vertebral bone destruction in sickle cell disease: infection, infarction or both.
Acute infarction of long bones in children with sickle cell anemia.
Osteomyelitis in children with sickle cell disease: early diagnosis with contrast-enhanced CT.
Two children with sickle cell disease and osteomyelitis were treated and definitive treatment was delayed until computed tomography (CT) revealed a subperiosteal abscess, which resulted in prompt diagnosis and treatment.
Mandibular lesions of vasoocclusive origin in sickle cell hemoglobinopathy
In conclusion, vasoocclusive involvement should be taken into consideration when assessing painful episodes or neurological symptoms in the maxillofacial region in this patient population.
Sickle cell disease and silent avascular necrosis of the hip.
We reviewed the prevalence of avascular necrosis (AVN) in a series of patients with sickle cell disease, using radiography and magnetic resonance imaging. We found AVN of at least one hip in 11 of 27
Sickle cell disease with orbital infarction and epidural hematoma
Imaging findings are reported in a 16-year-old boy with sickle cell disease with orbital infarction and epidural hematoma, probably related to vaso-occlusive episodes and the tearing of small vessels.
Septic arthritis in patients with sickle-cell disease.
The presenting features, modes of treatment and sequelae of septic arthritis of 50 joints in 31 Nigerians with sickle-cell disease were studied prospectively over a 66-month period, and severe complications occurred in 76%, apparently due to delay in diagnosis, severity of illness and a high incidence of hip-joint infection.
Sickle cell dactylitis: histopathologic observations.
The histopathologic features of Sickle cell dactylitis observed at autopsy in a 9-month-old Negro infant with sickle cell disease (homozygous S) are described and are similar to those observed in experimental models in which the medullary blood supply is completely interrupted with sparing of the periosteal vascular bed.
Bone marrow necrosis in sickle cell disease: a description of three cases and a review of the literature.
The ominous prognosis ascribed to generalized BMn seems to reflect the poor outcome of such underlying conditions as leukemia; however, the prognosis of generalized BMN is not so poor in association with SCD and other nonmalignant states.