Bone health in people with epilepsy: Is it impaired and what are the risk factors?

@article{Pack2008BoneHI,
  title={Bone health in people with epilepsy: Is it impaired and what are the risk factors?},
  author={A. Pack},
  journal={Seizure},
  year={2008},
  volume={17},
  pages={181-186}
}
  • A. Pack
  • Published 2008
  • Medicine
  • Seizure
Diseases of the bone are becoming increasingly prevalent. Persons with epilepsy treated with antiepileptic drugs (AEDs) are at greater risk as evidenced by changes in bone turnover, osteoporosis, alterations in bone quality, and fracture. Biochemical indices of bone and mineral metabolism including calcium, vitamin D, parathyroid hormone, and bone turnover markers can be affected. AED exposure is a cause of secondary osteoporosis with decreased bone mineral density (BMD) secondary to poor bone… Expand
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TLDR
Physicians should counsel patients taking AEDs about good bone health practices, and evaluation of bone health by measuring BMD is warranted after 5 years of AED treatment or before treatment in postmenopausal women. Expand
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TLDR
People with epilepsy who take nutritional supplementation have 25% lower s-Hcy levels than those who do not, which supports previous research, which found elevated s- Hcy in subjects taking AEDs and that bone loss is related to the use of enzyme-inducing AEDS and changes in alkaline phosphatase. Expand
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