Bone formation enhanced by implanted octacalcium phosphate involving conversion into Ca-deficient hydroxyapatite.

@article{Suzuki2006BoneFE,
  title={Bone formation enhanced by implanted octacalcium phosphate involving conversion into Ca-deficient hydroxyapatite.},
  author={Osamu Suzuki and Shinji Kamakura and Takenobu Katagiri and Masanori Nakamura and Baohong Zhao and Yoshitomo Honda and Ryutaro Kamijo},
  journal={Biomaterials},
  year={2006},
  volume={27 13},
  pages={2671-81}
}
The present study was designed to investigate whether hydrolysis of synthetic octacalcium phosphate (OCP) into hydroxyapatite affects bone formation. Mouse bone marrow stromal ST-2 cells and primary calvarial osteoblastic cells were cultured on the dishes pre-coated with OCP or its hydrolyzed Ca-deficient hydroxyapatite (OCP hydrolyzate; HL). The capacity of proliferation and differentiation was determined up to day 20. Granules of OCP and HL were implanted into critical-size rat calvaria… CONTINUE READING

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