Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment

  title={Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment},
  author={Georg Schett and Ellen M. Gravallese},
  journal={Nature Reviews Rheumatology},
Bone erosion is a central feature of rheumatoid arthritis and is associated with disease severity and poor functional outcome. Erosion of periarticular cortical bone, the typical feature observed on plain radiographs in patients with rheumatoid arthritis, results from excessive local bone resorption and inadequate bone formation. The main triggers of articular bone erosion are synovitis, including the production of proinflammatory cytokines and receptor activator of nuclear factor κB ligand… CONTINUE READING
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