Bone-derived stem cells repair the heart after myocardial infarction through transdifferentiation and paracrine signaling mechanisms.

Abstract

RATIONALE Autologous bone marrow-derived or cardiac-derived stem cell therapy for heart disease has demonstrated safety and efficacy in clinical trials, but functional improvements have been limited. Finding the optimal stem cell type best suited for cardiac regeneration is the key toward improving clinical outcomes. OBJECTIVE To determine the mechanism… (More)
DOI: 10.1161/CIRCRESAHA.113.301202

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Cite this paper

@article{Duran2013BonederivedSC, title={Bone-derived stem cells repair the heart after myocardial infarction through transdifferentiation and paracrine signaling mechanisms.}, author={Jason M. Duran and Catherine A. Makarewich and Thomas E. Sharp and Timothy Starosta and Fang Zhu and Nicholas E. Hoffman and Yumi Chiba and Muniswamy Madesh and Remus M. Berretta and Hajime Kubo and Steven R. Houser}, journal={Circulation research}, year={2013}, volume={113 5}, pages={539-52} }