Bone density phenotypes in mice aneuploid for the Down syndrome critical region.

@article{Olson2011BoneDP,
  title={Bone density phenotypes in mice aneuploid for the Down syndrome critical region.},
  author={Lisa E. Olson and Subburaman Mohan},
  journal={American journal of medical genetics. Part A},
  year={2011},
  volume={155A 10},
  pages={
          2436-45
        }
}
Down syndrome (trisomy 21) is associated with reduced bone density in humans, but it is unclear whether this is due to specific effects of chromosome 21 genes or lifestyle factors. Mouse models with aneuploidy of segments of mouse chromosome 16 that are homologous to human chromosome 21 can be used to elucidate the mechanism by which Down syndrome phenotypes arise. Ts1Rhr and Ms1Rhr mice are trisomic and monosomic, respectively, for the hypothesized "Down syndrome critical region" containing… CONTINUE READING
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