Bone cancer pain: the effects of the bisphosphonate alendronate on pain, skeletal remodeling, tumor growth and tumor necrosis.

@article{Sevcik2004BoneCP,
  title={Bone cancer pain: the effects of the bisphosphonate alendronate on pain, skeletal remodeling, tumor growth and tumor necrosis.},
  author={Molly A Sevcik and Nancy M. Luger and David B. Mach and Mary Ann C. Sabino and Christopher M. Peters and Joseph R. Ghilardi and Matthew J. Schwei and Heidi Roehrich and Carmen de Felipe and Michael A. Kuskowski and Patrick W Mantyh},
  journal={Pain},
  year={2004},
  volume={111 1-2},
  pages={169-80}
}
Patients with metastatic breast, lung or prostate cancer frequently have significant bone cancer pain. In the present report we address, in a single in vivo mouse model, the effects the bisphosphonate alendronate has on bone cancer pain, bone remodeling and tumor growth and necrosis. Following injection and confinement of green fluorescent protein-transfected murine osteolytic tumor cells into the marrow space of the femur of male C3H/HeJ mice, alendronate was administered chronically from the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

Similar Papers

Loading similar papers…