Bone and muscle protective potential of the prostate-sparing synthetic androgen 7alpha-methyl-19-nortestosterone: evidence from the aged orchidectomized male rat model.

@article{Venken2005BoneAM,
  title={Bone and muscle protective potential of the prostate-sparing synthetic androgen 7alpha-methyl-19-nortestosterone: evidence from the aged orchidectomized male rat model.},
  author={Katrien Venken and Steven Boonen and Erik van Herck and Liesbeth Vandenput and N. Vinod Kumar and R{\'e}gine L Sitruk-Ware and K Adhi vairava Sundaram and R Bouillon and Dirk Vanderschueren},
  journal={Bone},
  year={2005},
  volume={36 4},
  pages={663-70}
}
This study reports the preclinical evaluation of the bone and muscle protective potential of the synthetic androgen 7alpha-methyl-19-nortestosterone (MENTtrade mark), as assessed in the aged orchidectomized rat model. Aged (13-month-old) orchidectomized Wistar rats were treated with different doses of MENT (4, 12 or 36 microg/day) subcutaneously for 16 weeks via mini-osmotic pumps. Analysis of the effects of androgen deficiency versus MENT replacement was performed using quantitative computed… CONTINUE READING