Bone and calcium metabolism and antiepileptic drugs.

  title={Bone and calcium metabolism and antiepileptic drugs.},
  author={Alberto Verrotti and Giangennaro Coppola and Pasquale Parisi and Angelika Mohn and Francesco G Chiarelli},
  journal={Clinical neurology and neurosurgery},
  volume={112 1},
There is increasing evidence suggesting that epilepsy and its treatment can affect bone mineralization and calcium metabolism. Many studies have shown a significant reduction in bone mineral density in patients treated with classic (phenobarbital, carbamazepine, valproate, etc.) and with new (oxcarbazepine, gabapentin) antiepileptic drugs. In spite of data about the possible effects of the antiepileptic drugs on calcium metabolism, the mechanisms of this important side effect remain to be… CONTINUE READING