Bone and bone marrow pro-osteoclastogenic cytokines are up-regulated in osteoporosis fragility fractures

@article{DAmelio2010BoneAB,
  title={Bone and bone marrow pro-osteoclastogenic cytokines are up-regulated in osteoporosis fragility fractures},
  author={Patrizia D’Amelio and Ilaria Roato and Lucia D’Amico and Luciana Veneziano and Ethel Suman and Francesca Sassi and Giuseppina Bisignano and Riccardo Ferracini and G. Gargiulo and Francesca Castoldi and Gian Piero Pescarmona and Giovanni Carlo Isaia},
  journal={Osteoporosis International},
  year={2010},
  volume={22},
  pages={2869-2877}
}
This study evaluates cytokines production in bone and bone marrow of patients with an osteoporotic fracture or with osteoarthritis by real time PCR, Western blot and immunohistochemistry. We demonstrate that the cytokine pattern is shifted towards osteoclast activation and osteoblast inhibition in patients with osteoporotic fractures. Fragility fractures are the resultant of low bone mass and poor bone architecture typical of osteoporosis. Cytokines involved in the control of bone cell… CONTINUE READING

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The role of circulating bone cell precursors in fracture healing

  • P DAmelio, MA Cristofaro, +5 authors GC Isaia
  • Calcif Tissue Int
  • 2010

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