Bone Response to In Vivo Mechanical Loading in Two Breeds of Mice

@article{Akhter1998BoneRT,
  title={Bone Response to In Vivo Mechanical Loading in Two Breeds of Mice},
  author={Mohammed P. Akhter and Diane M. Cullen and Elisabeth A. Pedersen and Donald B. Kimmel and Robert Roy Recker},
  journal={Calcified Tissue International},
  year={1998},
  volume={63},
  pages={442-449}
}
We investigated the bone response to external loading in C57BL/6J and C3H/HeJ mice, both breeds with low and high bone density, respectively. An in vivo tibial four-point bending device previously used for application of measured external loads in rats was adapted for mice. It delivered a uniform medio-lateral bending moment to the region of the tibia located 1–5.5 mm proximal to the tibio-fibula junction. The right legs of six C57BL/6J [low bone density (LBD)] and C3H/HeJ [high bone density… CONTINUE READING
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