Bone Resorbing Osteoclasts Reveal Two Basal Plasma Membrane Domains and Transcytosis of Degraded Matrix Material

@inproceedings{Salo2002BoneRO,
  title={Bone Resorbing Osteoclasts Reveal Two Basal Plasma Membrane Domains and Transcytosis of Degraded Matrix Material},
  author={Jari Salo and Kalervo V{\"a}{\"a}n{\"a}nen and Jorma Keski-Oja},
  year={2002}
}
Changes of cellular polarity in osteoclasts during resorption cycle was studied. Targeting of vesicular stomatitis virus (VSV) G-protein has earlier been studied in epithelial cells and in neurons, in which it serves as a basolateral or dendritic marker protein, respectively. In osteoclasts it occupied only the peripheral parts of the circulation facing basal membrane, but not ruffled border membrane or sealing zone area. Apical or axonal markers including Influenza A haemagglutinin were… CONTINUE READING

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