Bone Remodeling

@article{Hadjidakis2006BoneR,
  title={Bone Remodeling},
  author={Dimitrios J Hadjidakis and Ioannis I. Androulakis},
  journal={Annals of the New York Academy of Sciences},
  year={2006},
  volume={1092}
}
Abstract:  The skeleton is a metabolically active organ that undergoes continuous remodeling throughout life. Bone remodeling involves the removal of mineralized bone by osteoclasts followed by the formation of bone matrix through the osteoblasts that subsequently become mineralized. The remodeling cycle consists of three consecutive phases: resorption, during which osteoclasts digest old bone; reversal, when mononuclear cells appear on the bone surface; and formation, when osteoblasts lay down… Expand
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Pathophysiology of Osteoporosis
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Development of drugs to prevent TRAF3 degradation in immune and bone cells could be a novel therapeutic approach to prevent or reduce bone loss and the incidence of several common diseases associated with aging. Expand
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It is postulate that osteocytes may have a pivotal role in bone regeneration as well, and consequently that the bone regeneration process may be improved effectively and rapidly if osteocytes are optimally used and stimulated. Expand
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Establishment of a fibrinolytic factor-targeting method efficiently promoting bone repair/regeneration and fracture healing, and development of a new osteoporosis treatment method and diagnostic marker are awaited. Expand
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TLDR
Findings suggest that osteocyte-related cytokines act directly to enhance osteoclast formation and bone resorption, and discuss the osteocyte as the master regulator of bone Resorption and effector in osteoc last formation. Expand
Newly formed and remodeled human bone exhibits differences in the mineralization process.
TLDR
The mineralization process is distinctively different between modeling and remodeling sites due to varying requirements for the transport distance and, therefore, the stability of non-crystalline ionic precursors, resulting in distinct compositions of the deposited mineral phase. Expand
The molecular mechanism behind bone remodelling: a review
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This publication aims to review molecular and biochemical insights with respect to the bone remodelling process, which is of fundamental importance for craniofacial growth, orthodontic tooth movement and regenerative dentistry. Expand
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