Bone Remodeling

@article{Hadjidakis2006BoneR,
  title={Bone Remodeling},
  author={Dimitrios J Hadjidakis and Ioannis I. Androulakis},
  journal={Annals of the New York Academy of Sciences},
  year={2006},
  volume={1092}
}
Abstract:  The skeleton is a metabolically active organ that undergoes continuous remodeling throughout life. Bone remodeling involves the removal of mineralized bone by osteoclasts followed by the formation of bone matrix through the osteoblasts that subsequently become mineralized. The remodeling cycle consists of three consecutive phases: resorption, during which osteoclasts digest old bone; reversal, when mononuclear cells appear on the bone surface; and formation, when osteoblasts lay down… 
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545 Citations

The Role Of BMPs in the Regulation of Osteoclasts Resorption and Bone Remodeling: From Experimental Models to Clinical Applications

Current knowledge of BMP signaling in osteoclasts, its role in osteoclast resorption, bone remodeling, and osteoblast–osteoclast coupling is summarized and discussion of clinical application of recombinant BMP therapy is based on recent preclinical and clinical studies.

Pathophysiology of Osteoporosis

  • S. Ferrari
  • Biology, Engineering
    Pocket Reference to Osteoporosis
  • 2018
After the completion of growth, the bone size and mineral content have reached its peak and will be maintained more or less unchanged during the adult life in absence of pathophysiological conditions thanks to moderate levels of bone remodeling that are perfectly balanced between resorption and formation within each BMU.

Osteoblastogenesis regulation signals in bone remodeling

The present review summarized the recent discoveries related to osteoblast regulation from several signals, including transforming growth factor-β, bone morphogenetic proteins, Wnt signal, Notch, Eph–Ephrin interaction, parathyroid hormone/parathyroid hormones-related peptide, and the leptin–serotonin–sympathetic nervous systemic pathway.

RANKL regulates RAW 264 . 7 cell osteoclastogenesis in a manner

The osteoclastic differentiation and activation are triggered mainly by osteoblast cells and vice versa, and the major biological regulators of bone remodeling include parathyroid hormone and calcitriol as well as other hormones.

Bone Remodeling and the Role of TRAF3 in Osteoclastic Bone Resorption

Development of drugs to prevent TRAF3 degradation in immune and bone cells could be a novel therapeutic approach to prevent or reduce bone loss and the incidence of several common diseases associated with aging.

Is There a Governing Role of Osteocytes in Bone Tissue Regeneration?

It is postulate that osteocytes may have a pivotal role in bone regeneration as well, and consequently that the bone regeneration process may be improved effectively and rapidly if osteocytes are optimally used and stimulated.

Osteoimmunological Aspects on Inflammation and Bone Metabolism

The RANK/RANKL/OPG-system is actively involved in the differentiation and function of osteoclasts and is known to play a central role in the majority of pathophysiological mechanisms.

Osteocyte-Related Cytokines Regulate Osteoclast Formation and Bone Resorption

Findings suggest that osteocyte-related cytokines act directly to enhance osteoclast formation and bone resorption, and discuss the osteocyte as the master regulator of bone Resorption and effector in osteoc last formation.

Roles of fibrinolytic factors in the alterations in bone marrow hematopoietic stem/progenitor cells during bone repair

Establishment of a fibrinolytic factor-targeting method efficiently promoting bone repair/regeneration and fracture healing, and development of a new osteoporosis treatment method and diagnostic marker are awaited.

Newly formed and remodeled human bone exhibits differences in the mineralization process.

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