Bone Morphogenetic Proteins in Bone Stimulate Osteoclasts and Osteoblasts During Bone Development

  title={Bone Morphogenetic Proteins in Bone Stimulate Osteoclasts and Osteoblasts During Bone Development},
  author={Mina Okamoto and Junko Murai and Hideki Yoshikawa and Noriyuki Tsumaki},
  journal={Journal of Bone and Mineral Research},
In this study, overexpression of noggin, a BMP antagonist, in developing bone caused significantly decreased osteoclast number as well as bone formation rate, resulting in increased bone mass with immature bone quality. BMP signaling plays important roles in normal bone development and regulation of bone resorption. 

The Bone Morphogenetic Protein Pathway: The Osteoclastic Perspective

This review aims to summarize the current knowledge of BMP signaling within the osteoclast lineage, its role in bone resorption, and osteoblast–osteoclast coupling, and subsequent clinical implications for recombinant BMP therapy.

The Role Of BMPs in the Regulation of Osteoclasts Resorption and Bone Remodeling: From Experimental Models to Clinical Applications

Current knowledge of BMP signaling in osteoclasts, its role in osteoclast resorption, bone remodeling, and osteoblast–osteoclast coupling is summarized and discussion of clinical application of recombinant BMP therapy is based on recent preclinical and clinical studies.

New insights on the roles of BMP signaling in bone-A review of recent mouse genetic studies.

The physiological function of BMP signaling in bone will be focused, and the current outcomes from mouse genetic studies will be discuss.

The Role of BMP Signaling in Osteoclast Regulation

The dual effect of BMPs on bone resorption and mineralization highlights the essential role of B MP-signaling in bone homeostasis, making it a putative therapeutic target for diseases like osteoporosis.

Expression and Synthesis of Bone Morphogenetic Proteins by Osteoclasts: A Possible Path to Anabolic Bone Remodeling

The data suggest a possible direct role for osteoclasts in promoting bone formation via expression and synthesis of BMPs, which then would play an important role in promoting the recruitment, proliferation, and differentiation of osteoblasts at bone resorption sites.

Interaction of bone morphogenetic proteins with cells of the osteoclast lineage: review of the existing evidence

There is evidence that these multifunctioning proteins affect bone resorption and the osteoclast homeostasis utilising various pathways and there are clinical implications of this supplementary role of the BMPs.

A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength

MBMPR1A–mFc stimulates osteoblastic bone formation and decreases bone resorption, which leads to an increase in bone mass, and offers a promising unique alternative for the treatment of bone-related disorders.

Disruption of BMP Signaling in Osteoblasts Through Type IA Receptor (BMPRIA) Increases Bone Mass

  • N. KamiyaL. Ye Y. Mishina
  • Biology, Medicine
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2008
Results suggest that Bmpr1a cKO increased endogenous bone mass primarily in trabecular bone with decreased osteoclastogenesis through the RANKL–OPG pathway.

BMP-6 and mesenchymal stem cell differentiation.




Skeletal overexpression of noggin results in osteopenia and reduced bone formation.

Transgenic mice overexpressing noggin in the bone microenvironment have decreased trabecular bone volume and impaired osteoblastic function, leading to osteopenia and fractures.

Bone Morphogenetic Protein Type IA Receptor Signaling Regulates Postnatal Osteoblast Function and Bone Remodeling*

Bone morphogenetic proteins (BMPs) function during various aspects of embryonic development including skeletogenesis. However, their biological functions after birth are less understood. To

Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton.

Excess BMP activity in the absence of Noggin antagonism may enhance the recruitment of cells into cartilage, resulting in oversized growth plates; chondrocytes are also refractory to joint-inducing positional cues.

The Bone Morphogenetic Proteins Antagonist Noggin Inhibits Membranous Ossification

It is shown that Noggin can modify bone formation in vivo in the adult animal and, thus, indirectly, that BMP signaling is indispensable in this process.

Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation

The effects of alterations in BMP receptor function targeted to the osteoblast lineage are shown and a necessary role of B MP receptor signaling in postnatal bone growth and bone formation in vivo is demonstrated.

Essential Requirement of BMPs‐2/4 for Both Osteoblast and Osteoclast Formation in Murine Bone Marrow Cultures from Adult Mice: Antagonism by Noggin

  • E. AbeMatsuo Yamamoto S. Manolagas
  • Biology, Medicine
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2000
It is suggested that BMP‐2 and −4 are expressed in the bone marrow in postnatal life and serve to maintain the continuous supply of osteoblasts and osteoclasts, and that, in fact, B MP‐2/4‐induced commitment to the osteoblastic lineage is a prerequisite for osteoclast development.

Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice.

The results provide compelling evidence that noggin, expressed in mature osteoblasts, inhibits osteoblast differentiation and bone formation, and the overproduction of noggins during biological aging may result in impaired osteoblow formation and function and hence, net bone loss.

Stimulatory effect of bone morphogenetic protein‐2 on osteoclast‐like cell formation and bone‐resorbing activity

  • M. KanataniT. Sugimoto K. Chihara
  • Biology, Medicine
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 1995
The present data are the first to indicate that BMP‐2 stimulates bone resorption through both direct stimulation of osteoclast formation and activation of mature osteoclasts, possibly via stromal cells, in vitro.