Bone Morphogenetic Proteins in Bone Stimulate Osteoclasts and Osteoblasts During Bone Development

@article{Okamoto2006BoneMP,
  title={Bone Morphogenetic Proteins in Bone Stimulate Osteoclasts and Osteoblasts During Bone Development},
  author={Mina Okamoto and Junko Murai and Hideki Yoshikawa and Noriyuki Tsumaki},
  journal={Journal of Bone and Mineral Research},
  year={2006},
  volume={21}
}
In this study, overexpression of noggin, a BMP antagonist, in developing bone caused significantly decreased osteoclast number as well as bone formation rate, resulting in increased bone mass with immature bone quality. BMP signaling plays important roles in normal bone development and regulation of bone resorption. 
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202 Citations
Highly Influential Citations
9
Background Citations
106
Methods Citations
2
Results Citations
8

202 Citations

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The data suggest a possible direct role for osteoclasts in promoting bone formation via expression and synthesis of BMPs, which then would play an important role in promoting the recruitment, proliferation, and differentiation of osteoblasts at bone resorption sites.

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Disruption of BMP Signaling in Osteoblasts Through Type IA Receptor (BMPRIA) Increases Bone Mass

  • N. KamiyaL. Ye Y. Mishina
  • Biology, Medicine
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2008
Results suggest that Bmpr1a cKO increased endogenous bone mass primarily in trabecular bone with decreased osteoclastogenesis through the RANKL–OPG pathway.

BMP-6 and mesenchymal stem cell differentiation.

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References

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Skeletal overexpression of noggin results in osteopenia and reduced bone formation.

Transgenic mice overexpressing noggin in the bone microenvironment have decreased trabecular bone volume and impaired osteoblastic function, leading to osteopenia and fractures.

Bone Morphogenetic Protein Type IA Receptor Signaling Regulates Postnatal Osteoblast Function and Bone Remodeling*

Bone morphogenetic proteins (BMPs) function during various aspects of embryonic development including skeletogenesis. However, their biological functions after birth are less understood. To…

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Excess BMP activity in the absence of Noggin antagonism may enhance the recruitment of cells into cartilage, resulting in oversized growth plates; chondrocytes are also refractory to joint-inducing positional cues.

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The present data are the first to indicate that BMP‐2 stimulates bone resorption through both direct stimulation of osteoclast formation and activation of mature osteoclasts, possibly via stromal cells, in vitro.