Bone Morphogenetic Proteins

@article{Chen2004BoneMP,
  title={Bone Morphogenetic Proteins},
  author={Di Chen and M. Zhao and G. Mundy},
  journal={Growth Factors},
  year={2004},
  volume={22},
  pages={233 - 241}
}
Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the transforming growth factor β (TGFβ) superfamily. The roles of BMPs in embryonic development and cellular functions in postnatal and adult animals have been extensively studied in recent years. Signal transduction studies have revealed that Smad1, 5 and 8 are the immediate downstream molecules of BMP receptors and play a central role in BMP signal transduction. Studies from transgenic and knockout mice and… Expand
BMP and BMP Inhibitors in Bone
  • V. Rosen
  • Chemistry, Medicine
  • Annals of the New York Academy of Sciences
  • 2006
TLDR
Identification of BMP antagonists allows us to investigate their role in diseases that affect skeletal function, such as osteopenia and nonunion fracture, and may provide a novel therapeutic intervention point for treatment. Expand
BMP and its antagonists
Bone morphogenetic protein (BMP) is necessary for the development of mesenchymal tissue and mesoderm formation during development. BMP2 and BMP4 play critical roles in morphogenesis. On the otherExpand
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TLDR
The structure of BMP-2, its activation and regulation signaling pathways, B MP-2 clinical applications, and limitations of using BMP -2 as a therapeutic are focused on. Expand
Bone Morphogenetic Protein Signaling: Implications in Urology
TLDR
D dorsomorphin, the first small molecule inhibitor of BMP signaling, was identified and suggested as a useful tool for dissecting the mechanisms of signaling pathways and for developing novel therapeutics for diverse human diseases that are related to the B MP signaling pathways. Expand
The role of bone morphogenetic proteins in ovarian function.
TLDR
It has become clear that the BMP system plays an important role in the regulation of ovarian function, evidenced by the ability of BMPs to control granulosa cell proliferation and cytodifferentiation, as well as oocyte development. Expand
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TLDR
This review focuses on all three types of BMPRI, which consist of activin-like kinase 2 (ALK2, also called type IA activin receptor), activin/threonine kinase 3 (ALK3,Also called BMPRIA), and Activin- like kinase 6 (ALK6), and the current progress regarding the roles of these receptors during myogenesis, chondrogenesis, and osteogenesis. Expand
BMPs: From Bone to Body Morphogenetic Proteins
TLDR
New insights on the roles of BMPs in various tissues are summarized and recent findings in cell, structural, and developmental biology as well as the therapeutic potential of B MPs are highlighted to conclude that BMP's today deserve to be called body morphogenetic proteins. Expand
Identification of a bone morphogenetic protein type 2 receptor neutralizing antibody
TLDR
This work sought to identify and validate an antibody that neutralizes the ligand-binding function of BMP receptor type 2 (BMPR2) extracellular domain (ECD) and found a dose-dependent inhibition of BMPR2-ECD lig and-binding. Expand
The Role of Bone Morphogenetic Protein 7 (BMP-7) in Inflammation in Heart Diseases
TLDR
This review focuses on the molecular mechanisms of BMP-7 treatment in cardiovascular disease and its role as an anti-fibrotic, anti-apoptotic and anti-inflammatory growth factor, which emphasizes its potential therapeutic significance in heart diseases. Expand
Transcription factors—Intricate players of the bone morphogenetic protein signaling pathway
TLDR
The current knowledge on BMP pathway‐related TFs is summarized, focusing on those involved in the canonical BMP signaling pathway through the SMAD proteins. Expand
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References

SHOWING 1-10 OF 78 REFERENCES
Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation
TLDR
The effects of alterations in BMP receptor function targeted to the osteoblast lineage are shown and a necessary role of B MP receptor signaling in postnatal bone growth and bone formation in vivo is demonstrated. Expand
The bone morphogenetic protein family and osteogenesis
  • J. Wozney
  • Biology, Medicine
  • Molecular reproduction and development
  • 1992
TLDR
These studies demonstrate that the BMP mRNAs are spatially and temporally expressed appropriately for the proteins involved in the induction and development of cartilage and bone in the embryonic limb bud. Expand
Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.
TLDR
Results provide direct genetic evidence that BMP-4 is essential for several different processes in early mouse development, beginning with gastrulation and mesoderm formation. Expand
Mice lacking Bmp6 function.
TLDR
The defects in sternum development in BMP6 null mice are likely to be associated with a transient early expression of Bmp6 in the sternal bands, prior to ossification, and are slightly exacerbated in Bmp5/6 double mutant animals. Expand
The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb.
TLDR
It is demonstrated that in the absence of BMPRIB, BMP7 plays an essential role in appendicular skeletal development, and rather than having a unique role, BM PRIB has broadly overlapping functions with other BMP receptors during skeletal development. Expand
Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis.
TLDR
Results suggest that signaling through this type I BMP-2/4 receptor is not necessary for preimplantation or for initial postIMplantation development but may be essential for the inductive events that lead to the formation of mesoderm during gastrulation and later for the differentiation of a subset of mesodermal cell types. Expand
BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.
TLDR
In situ hybridization analysis showed that the absence of BMP-7 affects the expression of molecular markers of nephrogenesis, such as Pax-2 and Wnt-4 between 12.5 and 14.5 days postcoitum (dpc), which identifies B MP-7 as an inducer of neephrogenesis. Expand
Structural basis of BMP signalling inhibition by the cystine knot protein Noggin
TLDR
The crystal structure of the antagonist Noggin bound to BMP-7 is reported, which shows that Nogsgin inhibits BMP signalling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors. Expand
Novel regulators of bone formation: molecular clones and activities.
TLDR
Human complementary DNA clones corresponding to three polypeptides present in this BMP preparation have been isolated, and expression of the recombinant human proteins have been obtained, and each appears to be independently capable of inducing the formation of cartilage in vivo. Expand
Long bone geometry and strength in adult BMP-5 deficient mice.
TLDR
The data suggest that adult female mice have a more robust skeleton than males, relative to in vivo mechanical demands, and although the bones of short ear mice are smaller and weaker than in control animals, they appear to be biomechanically appropriate for the in vitro mechanical loads that they experience. Expand
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