Bone Morphogenetic Protein-7 and Connective Tissue Growth Factor: Novel Targets for Treatment of Renal Fibrosis?

@article{Nguyen2008BoneMP,
  title={Bone Morphogenetic Protein-7 and Connective Tissue Growth Factor: Novel Targets for Treatment of Renal Fibrosis?},
  author={Tri Quang Nguyen and Roel Goldschmeding},
  journal={Pharmaceutical Research},
  year={2008},
  volume={25},
  pages={2416-2426}
}
Renal fibrosis is the major determinant in progression of kidney disease and results from an inappropriate response to acute and chronic kidney injury. Transforming growth factor (TGF)-β1 is the driving force behind renal fibrosis and has since long been regarded as the key factor to be targeted in prevention and treatment of renal fibrosis. Despite the… CONTINUE READING