Bone Morphogenetic Protein-4 Acts as an Ovarian Follicle Survival Factor and Promotes Primordial Follicle Development1

@inproceedings{Nilsson2003BoneMP,
  title={Bone Morphogenetic Protein-4 Acts as an Ovarian Follicle Survival Factor and Promotes Primordial Follicle Development1},
  author={E. Nilsson and M. Skinner},
  booktitle={Biology of reproduction},
  year={2003}
}
  • E. Nilsson, M. Skinner
  • Published in Biology of reproduction 2003
  • Biology, Medicine
  • Abstract The growth and development of follicles within the ovary are highly dependent on autocrine and paracrine signaling involving growth factors from granulosa cells, theca cells, stromal interstitial cells, and the oocytes. The growth factor bone morphogenetic protein-4 (BMP-4) and its receptor (BMPR-IB) have been detected in ovaries, and a mutation in BMPR-IB has been associated with abnormal ovulation rate. The objective of the current study was to examine the role that BMP-4 plays in… CONTINUE READING
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