Bone Morphogenetic Protein-2 and -4 Limit the Number of Enteric Neurons But Promote Development of a TrkC-Expressing Neurotrophin-3-Dependent Subset

@article{Chalazonitis2004BoneMP,
  title={Bone Morphogenetic Protein-2 and -4 Limit the Number of Enteric Neurons But Promote Development of a TrkC-Expressing Neurotrophin-3-Dependent Subset},
  author={Alcm{\`e}ne Chalazonitis and Fabien D'autr{\'e}aux and Udayan Guha and Tuan Duc Pham and C Faure and Jason J. Chen and Daniel Roman and Li-xin Kan and Taube P. Rothman and John A. Kessler and Michael D. Gershon},
  journal={The Journal of Neuroscience},
  year={2004},
  volume={24},
  pages={4266 - 4282}
}
The hypothesis that BMPs (bone morphogenetic proteins), which act early in gut morphogenesis, also regulate specification and differentiation in the developing enteric nervous system (ENS) was tested. Expression of BMP-2 and BMP-4, BMPR-IA (BMP receptor subunit), BMPR-IB, and BMPR-II, and the BMP antagonists, noggin, gremlin, chordin, and follistatin was found when neurons first appear in the primordial bowel at embryonic day 12 (E12). Agonists, receptors, and antagonists were detected in… Expand
Bone morphogenetic proteins regulate enteric gliogenesis by modulating ErbB3 signaling.
TLDR
The hypotheses that BMPs are required for enteric gliogenesis and act by promoting responsiveness of ENCDC to ErbB3 ligands such as GGF2 are supported. Expand
BMP-Smad 1/5/8 signalling in the development of the nervous system
TLDR
How, following neural tube closure, the most dorsal aspect of the tube becomes a signalling centre for BMPs, which directs the pattern of the development of the dorsal spinal cord, through the action of Smad1, Smad5 and Smad8 is described. Expand
Bone morphogenetic protein regulation of enteric neuronal phenotypic diversity: Relationship to timing of cell cycle exit
The effects of bone morphogenetic protein (BMP) signaling on enteric neuron development were examined in transgenic mice overexpressing either the BMP inhibitor, noggin, or BMP4 under control of theExpand
BMP signaling is necessary for neural crest cell migration and ganglion formation in the enteric nervous system
TLDR
An essential role for BMP signaling in these aspects of ENS development is supported and provides a basis for further investigation of these proteins in the etiology of neuro-intestinal disorders. Expand
Pleiotropic effects of the bone morphogenetic proteins on development of the enteric nervous system
TLDR
BMP signaling limits total neuron numbers, favoring the differentiation of later born neuronal phenotypes at the expense of earlier born ones thus influencing the neuronal composition of the ENS and the glia/neuron ratio. Expand
The expression and crucial roles of BMP signaling in development of smooth muscle progenitor cells in the mouse embryonic gut.
TLDR
Taken together, BMP signaling was expressed for a short window in the smooth muscle progenitors and the signal, especially BMP2, plays an essential role in smooth muscle differentiation in cooperation with PDGF signaling. Expand
Bone morphogenetic protein 2 regulates the differentiation of nitrergic enteric neurons by modulating Smad1 signaling in slow transit constipation
TLDR
A new role is indicated for BMP-2 as an important transcriptional cofactor that regulates the differentiation of nitrergic enteric neurons through the Smad1 pathway and may be useful for the treatment of STC. Expand
Neurotrophine-3 may contribute to neuronal differentiation of mesenchymal stem cells through the activation of the bone morphogenetic protein pathway
TLDR
It is suggested that the BMP signaling pathway may be a key regulatory point in NT-3-transfected neuronal differentiation of MSCs and the transcription and expression of neural-specific genes and BMP-Smad signaling were significantly suppressed by siRNA-mediated knockdown of the TrkC gene of M SCs. Expand
BMP2 promotes differentiation of nitrergic and catecholaminergic enteric neurons through a Smad1-dependent pathway.
TLDR
The effects of BMP2 on catecholaminergic neurons may have therapeutic implications in gastrointestinal motility disturbances and the Smad signal transduction pathway has been implicated in TGF-beta signaling. Expand
BMP signaling pathway plays multiple roles during gastrointestinal tract development
The Bone Morphogenetic Protein (BMP) signaling pathway plays an essential role during gastrointestinal (GI) tract development in vertebrates. In the present study, we use an antibody that recognizesExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 123 REFERENCES
BMP-2 and BMP-4, but Not BMP-6, Increase the Number of Adrenergic Cells Which Develop in Quail Trunk Neural Crest Cultures
TLDR
Analysis using bromodeoxyuridine labeling indicated that the increased numbers of TH-immunoreactive cells observed in the presence of B MP-2 and BMP-4 were not due to an increased rate of cell division in committed TH precursors. Expand
Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development.
TLDR
Evidence is provided that BMPs function during regional morphogenesis of the dorsal telencephalon by regulating specific gene expression, cell proliferation and local cell death. Expand
Multiple Roles of Bone Morphogenetic Protein Signaling in the Regulation of Cortical Cell Number and Phenotype
TLDR
Results support the hypothesis that the BMPs and their antagonist noggin co-regulate cortical cell fate and morphogenesis and suggest that local concentrations of ligands and antagonists define gradients of BMP signaling during corticogenesis. Expand
Development of Bone Morphogenetic Protein Receptors in the Nervous System and Possible Roles in Regulating trkC Expression
TLDR
In situ hybridization analyses demonstrate that BMP-specific type I and type II receptor mRNAs are expressed at significant levels in multiple regions of the CNS, cranial ganglia, and peripheral sensory and autonomic ganglia during the embryonic and neonatal periods. Expand
Bone morphogenetic proteins in the nervous system
TLDR
Bone morphogenetic proteins act on more lineage-restricted embryonic CNS progenitor cells to promote regional neuronal survival and cellular differentiation and induce selective apoptosis of discrete rhombencephalic neural crest-associated cellular populations. Expand
Target-derived BMP signaling limits sensory neuron number and the extent of peripheral innervation in vivo
TLDR
Transgenic animals examined in transgenic animals that overexpress either the BMP inhibitor noggin or BMP4 under the control of a keratin 14 (K14) promoter indicated that the normal developmental decrease in neuron numbers in sensory ganglia depends upon BMP signaling, and that BMPs may limit both the final neuron number and the extent of innervation of targets. Expand
Cloning and characterization of a human type II receptor for bone morphogenetic proteins.
TLDR
The cDNA cloning and characterization of a human type II receptor for BMPs (BMPR-II) is reported, which is distantly related to DAF-4, a BMP type II receptors from Caenorhabditis elegans. Expand
The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb.
TLDR
Exogenous administration of recombinant Gremlin indicates that this protein is involved in the control of limb outgrowth and the anti-apoptotic influence of exogenous Gremlin, which results in the formation of soft tissue syndactyly in the chick, indicates that Gremlin regulates the regression of the interdigital tissue. Expand
Bone morphogenetic proteins induce apoptosis and growth factor dependence of cultured sympathoadrenal progenitor cells.
TLDR
The effects of bone morphogenetic proteins in inducing apoptosis of MAH cells, an immortalized sympathoadrenal progenitor cell line, are examined to suggest that neuron numbers may be regulated by factors which promote death and that exposure to such factors may be a signal for the development of dependence upon other growth factors for survival. Expand
Msx-2 and p21 mediate the pro-apoptotic but not the anti-proliferative effects of BMP4 on cultured sympathetic neuroblasts.
TLDR
Although treatment of cultured E14 sympathetic neuroblasts with neurotrophins alone did not alter cell numbers, BMP4-induced cell death was prevented by co-treatment with either neurotrophin-3 (NT-3) or nerve growth factor (NGF), which suggests that B MP4 may also induce dependence of the cells on neurotrophs for survival. Expand
...
1
2
3
4
5
...