Bone Marrow Alterations and Lower Endothelial Progenitor Cell Numbers in Critical Limb Ischemia Patients

@inproceedings{Teraa2013BoneMA,
  title={Bone Marrow Alterations and Lower Endothelial Progenitor Cell Numbers in Critical Limb Ischemia Patients},
  author={Martin Teraa and Ralf W Sprengers and Peter E. Westerweel and Hendrik Gremmels and Marie-Jos{\'e} T H Goumans and Tom Teerlink and Frans L Moll and Marianne C Verhaar},
  booktitle={PloS one},
  year={2013}
}
BACKGROUND Critical limb ischemia (CLI) is characterized by lower extremity artery obstruction and a largely unexplained impaired ischemic neovascularization response. Bone marrow (BM) derived endothelial progenitor cells (EPC) contribute to neovascularization. We hypothesize that reduced levels and function of circulating progenitor cells and alterations in the BM contribute to impaired neovascularization in CLI. METHODS Levels of primitive (CD34(+) and CD133(+)) progenitors and CD34(+)KDR… CONTINUE READING
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