Bone Markers, Calcium Metabolism, and Calcium Kinetics During Extended‐Duration Space Flight on the Mir Space Station

  title={Bone Markers, Calcium Metabolism, and Calcium Kinetics During Extended‐Duration Space Flight on the Mir Space Station},
  author={Scott M Smith and Meryl E Wastney and Kimberly O O'Brien and Boris V. Morukov and Irina M. Larina and Steven A. Abrams and Janis E. Davis-Street and Victor Sumbatovich Oganov and Linda C. Shackelford},
  journal={Journal of Bone and Mineral Research},
Bone loss is a current limitation for long‐term space exploration. Bone markers, calcitropic hormones, and calcium kinetics of crew members on space missions of 4–6 months were evaluated. Spaceflight‐induced bone loss was associated with increased bone resorption and decreased calcium absorption. 

Fifty years of human space travel: implications for bone and calcium research.

Calcium and bone metabolism remain key concerns for space travelers, and ground-based models of space flight have provided a vast literature to complement the smaller set of reports from flight

Bone metabolism and renal stone risk during International Space Station missions.

Men and Women in Space: Bone Loss and Kidney Stone Risk After Long‐Duration Spaceflight

The response of urinary supersaturation risk to spaceflight was not significantly different between men and women, although risks were typically increased after flight in both groups, and risks were greater in men than in women before and after flight.

Effect of Age‐Related Chronic Immobility on Markers of Bone Turnover

  • Jing ChenI. Cameron M. Seibel
  • Medicine
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2006
The effects of acute immobilization on bone turnover are well known, but the effects of chronic hypomobility with aging have not been studied and the effect of immobility may be more marked on bone formation than on bone resorption.

Space Flight Calcium: Implications for Astronaut Health, Spacecraft Operations, and Earth

A novel technique using natural stable isotopes of calcium that will be helpful in the future to determine calcium and bone balance during space flight is discussed.

Bisphosphonates as a supplement to exercise to protect bone during long-duration spaceflight

The combination of exercise plus an antiresoptive drug may be useful for protecting bone health during long-duration spaceflight.

Nutrition and Bone Health in Space

The history of research on bone mineral loss during space flight is reviewed and a summary of recent and ongoing studies, including efforts to counteract bone and calcium loss resulting from weightlessness are provided.

Dietary acid load and bone turnover during long-duration spaceflight and bed rest.

Long-term lowering of NEAP by increasing vegetable and fruit intake may protect against changes in loss of bone mineral content during spaceflight when adequate calcium is consumed, particularly if resistive exercise is not being performed.

Adaptation of the Skeletal System During Long-Duration Spaceflight

This review will highlight evidence from crew members flown on space missions >90 days to suggest that the adaptations of the skeletal system to mechanical unloading may predispose crew members to an

Calcium and bone metabolism during space flight.

Calcium metabolism before, during, and after a 3-mo spaceflight: kinetic and biochemical changes.

Results from Skylab missions in the 1970s are extended to determine the time course of changes in calcium homeostasis during flight to develop and assess countermeasures against flight-induced bone loss.

Mineral and Nitrogen Metabolic Studies, Experiment M071

It is concluded that capable musculoskeletal function is likely to be impaired during space flights of 1 1/2 to 3 years duration.

Bone formation and resorption biological markers in cosmonauts during and after a 180-day space flight (Euromir 95).

It is shown for the first time in humans that microgravity induced an uncoupling of bone remodeling between formation and resorption that could account for bone loss.

The Effects of Twelve Weeks of Bed Rest on Bone Histology, Biochemical Markers of Bone Turnover, and Calcium Homeostasis in Eleven Normal Subjects

The human skeleton appears to respond to unloading by a rapid and sustained increase in bone resorption and a more subtle decrease in bone formation.

Bone mineral and lean tissue loss after long duration space flight.

The data define the rate and extent of bone and lean tissue loss during long duration space flight and indicate that the current in-flight exercise program is not sufficient to completely ameliorate bone and muscle loss during weightlessness.

Effects of 1-week head-down tilt bed rest on bone formation and the calcium endocrine system.

The similarity of the response of bone and the calcium endocrine system of healthy men after only 7 days to results of longer term bed rest studies emphasizes the responsiveness of the adult human skeleton to biomechanical stimuli induced by changes in activity and/or position.

Collagen cross-link excretion during space flight and bed rest.

Assessment of excretion of PYD cross-links and N-telopeptide before, during, and after long and short Skylab missions, as well as during short and long bed-rest studies, shows that changes in bone metabolism associated with space flight involve increased resorption.